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Abandon hope all ye target theory modelers...



Hello All,



The latest issue of Mutation Research 568 (2004) is devoted to the combined effects of Adaptive Response, Bystander Effects and Genomic Instability from low doses of ionizing radiation. The conclusions of the dozen or so review articles are that the dose response at low dose and low dose rates is decidedly non-linear. 



http://www.sciencedirect.com/science?_ob=IssueURL&_tockey=%23TOC%234915%232004%23994319998%23527311%23FLA%23Volume_568,_Issue_1,_Pages_1-143_(2_December_2004)%2BMAdaptation,_Instability,_and_Bystander_Effects_Following_Low_Level_Radiation_Exposure%2BMEdited_by_J._L._Schwartz&_auth=y&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4f3333d6cfa038136f2a414e0b526ab3



Just remember that Hermann J. Müller's famous work that spawned target theory was based on an inappropriate model for generalization to organisms. He used fruit fly sperm cells which have no intercellular communication or repair.



"Using MS Windows these days is like setting your hair on fire and putting it out with a hammer."--Charles Moore

Michael D. Brooks, CHP 

Senior Health Physicist

CDC/ATSDR 1600 Clifton Road, NE (E-32) 

Atlanta, GA 30333

(404) 498-0360 (office)

(404) 285-3083 (cell)

(404) 498-0416 (fax)

mdb7@cdc.gov

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