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Re: Abandon hope all ye target theory modelers...
At 07:17 AM 11/19/2004, Brooks, Michael wrote:
>Just remember that Hermann J. Müller's famous work that spawned target
>theory was based on an inappropriate model for generalization to
>organisms. He used fruit fly sperm cells which have no intercellular
>communication or repair.
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November 22, 2204
The linear observations of H.J. Muller (SCIENCE 66: 84-87, 1927) are not
applicable to radiation carcinogenesis. New research by Koana et al.
(RADIATION RESEARCH 161, 391-396, 2004) shows that somatic cell mutations
from ionizing radiation exposures are non-linear and even suggests a
hormesis effect.
Otto
**********************************************
Prof. Otto G. Raabe, Ph.D., CHP
Center for Health & the Environment
(Street Address: Bldg. 3792, Old Davis Road)
University of California, Davis, CA 95616
E-Mail: ograabe@ucdavis.edu
Phone: (530) 752-7754 FAX: (530) 758-6140
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