Re: Y-90 synovectomy

[CHATHO@delphi.com]

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> Date: Fri, 16 Jun 1995 09:25:53 -0500
> From: mem122a@lanl.gov (Milton McLain)
> Subject: Re: Y-90 synovectomy
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> >Is anyone working in a US facility where Y-90 is being used for radiation
> >synovectomy (presumably under an IND)? I know it is used in the UK and
> >elswhere in Europe. We have a pediatric hemophiliac patient we wish to refer
> >for this procedure. The physicians prefer NOT to use P-32 unless necessary.
> >
> >NUCPHARM@AOL.COM
> >W. Porter, BCNP  313-876-3217 PHONE
> >                           313-876-1087 FAX
> >
> 
> 
> 
> Sir:
> 
> Back in the dark ages, i.e. late 60's - early 70's, considerable work using
> Y-90 for this therapy was done at the Georgia Tech Nuclear Research Center.
> At the time it was limited to animal experiments.  Y-90 was produced by both
> irradiation of stable Y-89 oxide in the reactor and from a one-curie Sr-90
> generator (a real BEAST).  The prime questions addressed by these animal
> studies was to define the distribution of the injected Y-90 within the
> organs.  In other words, how well the Y-90 remained in the injected joint.
> The "normal" chemical form for the injected Y-90 was a suspension of Y
> hydroxide, obtained by neutralizing an acidic solution of Y nitrate.
> 
> The physician involved in these studies has, no doubt, retired.  You might
> contact Ratib Karam  or Rod Ice at Ga. Tech for possible update.
> 
> 
> Milton McLain
> 
> 
During the same ancient time period the Western New York Nuclear Research
Center of SUNY/Buffalo Was producing Y-90 needles for the Cleveland Clinic.  I 
don't remember if there were any others we were shipping to.  As I remember
they were being used for human treatment. 

Charles C. Thomas, Jr.