Re: Research Human Use Users

[scherer@uiuc.edu (David Scherer)]

>The changes in Part 35 made last winter added "research" use to
>most of the human use areas defined in this Part.  As a result
>specific training requirments, survey requirements and testing
>requiremnts now apply to low level human research using isotopes
>like H-3 and C-14.  Our RSC is presently discussing the
>implications of this and the meaning of requirement like the
>linearity test as applied to a LSC counter that uses one type vial
>and a specific activity and volume of solvent.  I'd appreciate any
>insights some of you may have applied to these questions.

The linearity test evaluates how the instrument responds to different sample
activities.  This would seem to be as valid for a LSC as for an ion chamber
dose calibrator.  However, the questions you raise would apply to the
geometric variation test.  It seems to me that the corresponding test in LSC
would be the quench curves.  The policy behind the rule is to measure every
dose before administering it to a patient/research subject and that the
measurement should be corrected for known sources of error.

Dave Scherer
scherer@uiuc.edu