Re: Re[2]: Thyroidectomy/Thyroid Burden Measurements -Forwa

["Dr. M. Pillay -DDHK Nuclear Medicine" <pillay@ngoh.azr.nl>]

> Datum verzending: Thu, 22 Feb 1996 18:45:16 +0100
> Stuur antw. aan:  radsafe@romulus.ehs.uiuc.edu
> Van:              michael_coogen@ccgw1.hq.dla.mil
> Aan:              Multiple recipients of list <radsafe@romulus.ehs.uiuc.edu>
> Onderwerp:        Re[2]: Thyroidectomy/Thyroid Burden Measurements -Forwarded 


    A point to note is that total thyroidectomy is most often a 
result of thyroid cancer. This increases the probability of distant 
metastases, most likely of thyroid tissue. In our nucl. med facility, 
a I-131 total body scan is performed to locate these mets, very often 
in the thorax, abdomen, and seldom in bone. The presence of these 
mets. will determine the clearance of I-131. I might add, these mets. 
might be on the micro scale in size !

Mike Pillay
Dept. Nucl Med
Dr. Daniel den Hoed Cancer Center
Rotterdam. Netherlands.

 
>      We as individuals are unique unto ourselves.  We are genetically 
>      different.  I'm not familar with Mike's 6 hour clearance half life but 
>      you must take into account the following:
>      
>         Different metabolic rate
>         Post Thyroidectomy
>         Age of Patient
>         Resposnse to the radiopharmaceutical
>      
>      You can give 10 patients Iodine-131 and in most cases you will have 
>      different metabolic responses, depending upon how much of residual 
>      thyroid gland was left behind.  Surgeons remove as much as they can 
>      and that depends upon the etiology and condition of the patient.  Each 
>      patient is different and each patient will respond different.  In fact 
>      if you increase the therpay to a larger population you will see the 
>      deviations more statistical....Cannot rationalize or conclude anything 
>      from one patient..You must accept it for what it is...mike coogen
> 
> 
> ______________________________ Reply Separator _________________________________
> Subject: Re: Thyroidectomy/Thyroid Burden Measurements -Forwarded -Re
> Author:  radsafe@romulus.ehs.uiuc.edu at ~GW1
> Date:    2/22/96 10:16 AM
> 
> 
> We monitor I-131 therapy patients given 100-200 mCi to determine when 
> they drop below the 30 mCi outpatient limit.  In our crude way
> of doing things we usually see an apparent 24 hr clearance half life. 
> Younger/healthier patients may be quite a bit faster than this, but 
> some patients are longer.  Given that our technique of measuring
> dose rate at 1 meter is crude, how do we explain our observations 
> given Mike's 6 hour clearance half-life?
>      
> Dale Boyce
> dale@radpro.uchicago.edu
> 
>