Re: MIRD2

[Bruce Busby <bbusby@umich.edu>]

MIRD 3 is available from ORAU at the web site :

http://www.orau.gov/ehsd/ridic.htm

the Radiation Internal Dose Information Center (RIDIC) at the Oak Ridge
Institute for Science and Education
(ORISE) has been distributing various versions of the MIRDOSE software
since 1987. MIRDOSE performs internal
dose calculations according to the MIRD technique for many radionuclides
commonly used in nuclear medicine
(NOTE: the software is NOT in any way associated with the MIRD Committee
of the Society of Nuclear Medicine).
Its main purpose is to perform the calculations that are needed to obtain
dose estimates for the various organs of the
body once the kinetics of an agent are established and the residence times
or areas under the time-activity curves for
the various source organs are established. The code's other purpose is to
help the user apply standardized, recognized
models and techniques for dosimetry into the calculations. 

A recent publication (Journal of Nuclear Medicine 37:538-546, 1996)
outlined all of the assumptions and techniques
employed both in versions 2.0 (1987) and 3.0 (1994) of the software.
MIRDOSE 3 now contains 10 different models
of the human bodyone for adult males and females, one representing
children of five different ages (developed by
Mark Cristy and Keith Eckerman of Oak Ridge National Laboratory [ORNL]),
and three representing the adult
woman during pregnancy (developed by Stabin et al. at ORISE and ORNL). It
has over 240 radionuclides available,
calculates doses from up to 28 source organs to as many as 27 target
organs, and reports the effective dose equivalent
(ICRP 26/30) and effective dose (ICRP 60) for any agent studied. 

MIRDOSE 3 includes several widely accepted standardized models or
techniques, including a dynamic urinary bladder
model, the ICRP 30 GI tract model, corrections for remainder of the body
activity, and a model for calculating
self-dose to small, unit-density spheres (such as tumors). In addition, it
contains a new bone and marrow model,
developed by Keith Eckerman of ORNL. This model gives not only an average
dose to red marrow from an agent, but
also gives the distribution of that dose throughout the skeleton for all
10 individuals modeled. It reports integral and
differential dose-volume histograms (DVHs) as well. MIRDOSE 3 runs in a
Windows environment, with on-line help,
and was designed to be easily learned and used by anyone who understands
the basics of the MIRD calculational
techniques.

The software is distributed by RIDIC free of charge. The only requirement
is that users sign a legal disclaimer form and
send RIDIC two unformatted 3.5-inch floppy disks and a self-addressed
stamped envelope for return (users outside
the United States may disregard the envelope requirement). To receive a
copy of the disclaimer form, you may contact
RIDIC as follows:

E-mail: smithf@orau.gov

Radiation Internal Dose Information Center
Oak Ridge Institute for Science and Education
P.O. Box 117
Oak Ridge, TN 37831-0117
Phone: +1 423 576 3478
FAX: +1 423 576 8673




I do recommend you contact the RIDIC folks.

-Bruce Busby