RADSAFE - S-35 Volatility Info

[Lisa Coronado <lcoronado@genetics.com>]

To:  RADSAFE
From:  Lisa Coronado
Re:  S-35 Volatility Issue

To add to Dr. Joe Ring's response, we have
noticed that the volatility is primarily associated
with S-35 labeled amino acids used for
investigating protein synthesis and genetic
regulation of this process.  The specific activity of
the material is usually around 1,494 Ci/mmol.  This
high specific activity accelerates the radiolytic
decomposition of the S-35 compound.  The
percent volatilized is reported as 0.004% -0.1%. 
Although the quantity is unlikely to reach maximum
permissible airborne concentrations, precautions
should be taken to avoid any possible internal
exposure (e.g., opening/venting in a fume hood or
charcoal trap).  Also, ordering the material in a
tricine stabilizer appears to reduce the volatility by
80%.  Additional info on this subject is available
from the suppliers (i.e., Amersham and
Dupont/NE) in the form of technical data sheets or
an MSDS.

Lisa Coronado
Deputy RSO
Genetics Institute, Inc.
Cambridge, MA
(617) 498-8407
lcoronado@genetics.com