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RE: I-131 TREATMENT AND PREGNANCY
The principal reason that a woman should delay becoming pregnant after
undergoing treatment for hyperthyroidism with I-131 has nothing to do with
radiation effects on ova or on the fetus. Rather the delay is prudent to
allow a sufficient period of time to determine that the hyperthyroidism has
been controlled. If hyperthyroidism persists or recurs (after an initial
apparent improvement) and the patient is pregnant, retreatment with I-131 is
absolutely contraindicated. Treating hyperthyroidism with drugs during
pregnancy can be difficult and poses hazards for the fetus. "Healthy mothers
make healthy babies."
Barry A. Siegel, M.D
Mallinckrodt Institute of Radiology
_______________________________________________________________________________
From: radsafe@romulus.ehs.uiuc.edu on 18 Jul 1997 21:26
Subject: Re: I-131 TREATMENT AND PREGNANCY
To: Multiple recipients of list
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#000#><p> <font size=+0>Dear Radsafers,</font>
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#000#><p> <font size=+0>Does anyone has an idea what should be the minimum
time
between
#000#> I-131 Thyroid ablation</font><font size=+0> Treatment and pregnancy.
The question
#000#> refers only to radiation protection of the fetus.</font>
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#000#><p> <font size=+0>Any information will be welcomed.</font>
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#000#><p> <font size=+0>Thanks,</font>
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#000#><p> <font size=+0>Moshe Levita</font>
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#000#><p> <font size=+0>Tel-Aviv Medical Center</font>
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#000#><p> <font size=+0>Israel</font>
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#000#><pre>----------------------------------------------<br>From : Moshe
Levita<mlevita@netvision.net.il><br>Date : 07/18/97,Time: 18:41:02 ,
ICQ # 523720<br>----------------------------------------------</pre>
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#000#>Advice in publications may vary from a few months to as many as 6
months.
I think that ICRP 52 suggested 6 months. But I this may be too cautious.
I would the advance the following points for consideration:
1. How long for patients whole body dose to fall to acceptable levels?
Assume an effective half life of X days up to 8 and
that Y half lives have elapsed.
2. Allow a margin for egg cells in a state of division at time of treatment
to be shed say Z menstrual cycles.
3. Allow time for the potential mother to be Euthyroid. After all there
should be reduced fertility in throtoxic women and
zero fertility in hypothyroid women.
4. If the subject is a male, say time for stored sperm to be
replaced.
So it would seem to me that any time after 3 - 6 months would be
appropriate. Empirivally I do not recall reading about any pregnany
problems related to prior 1-131 therapy in either parent.
Ivor Surveyor
Ivor Surveyor
Emeritus Consultant Physician, Nuclear Medicine.
E-mail: isurveyor@vianet.net.au
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From: isurveyor@vianet.net.au (Ivor Suveyor)
To: Multiple recipients of list <radsafe@romulus.ehs.uiuc.edu>
Subject: Re: I-131 TREATMENT AND PREGNANCY
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