Research Subject Doses

["Chuck Pickering" <CPICKERING@engr-serv.usc.edu>]

Happy Holidays,

All you Linear and Non-linear combatants please sharpen your pencils. 
I am reviewing a human subject research study that proposes to expose 
the subjects to a dose (TEDE) of 0.5 Rem. Extrapolating LINEARLY from 
BEIR 5 data suggests that the risk from participating in this study is 
about 4 deaths per 10,000 (10 Rem = 800 per 100,000). 

I am deliberately not giving you all the information on radionuclide, 
dose schedule, administered dose, etc. I am interested in your 
thoughts on extrapolating in this fashion and if you have suggestions 
on what the risk might be if one extrapolated using a non-linear 
method.

Chuck Pickering, RSO
University of Southern California
(213) 342-2200
(213) 342-2201 Fax
cpickering@engr-serv.usc.edu