Re: An interesting question related to permanant prostate implant

["Robert Denne" <rdenne@worldnet.att.net>]

Totally non-scientific answer here but my guess is yes it is safe to keep
the baby.  Would the baby have some genetic defect? I don't know.  Would a
genetically defective baby be safe with these parents?  I don't know either
but do have guess.
----- Original Message -----
From: Chris Alston <alstonc@odrge.odr.georgetown.edu>
To: Multiple recipients of list <radsafe@romulus.ehs.uiuc.edu>
Sent: Wednesday, September 15, 1999 2:47 PM
Subject: An interesting question related to permanant prostate implant


> >Here's what my friendly, neighborhood genetic counselor has told me (I
> >have not been able to check any other references yet): any individual
> >sperm are present and viable for about 3 months. Her sources say that a
> >dose greater than 1 rad is enough to pose a substantial threat of DNA
> >breakage. As we know, most of the DNA is non-coding. Damage to
> >non-coding areas may never be expressed. However, there is a concern of
> >chrmosome breakage, leading to crossovers, fragments, etc. This can be
> >picked up by amnioscentesis. It is also possible for damage to occur
> >causing an autosomal dominant mutation, which could either be lethal or
> > still yield a viable fetus. It's also possible that a recessive
> >mutation is formed that may or may not be expressed down the line. She
> >recommended ultrasound at 20 weeks to look for the effect of any
> >non-lethal autosomal dominant mutations. She also recommended
> >amnioscentesis for chromosomal damage. No surprise, she felt that the
> >patient (well, his partner) should talk to a knowlegeable genetic
> >counselor in her area and go over their genetic history to see if there
> >is also a specific risk they might be concerned about. I can get some
> >references to that end if needed. Hope this helps. (The normal risk of
> >genetic damage in a fetus is 3-5%.)
> >
> >Doug Pfeiffer
> >
> >--- "Haoran Jin, Ph.D." <hjin@EPIX.NET> wrote:
> >> A doctor in my area asked me an interesting question:  A gentleman
> >> received
> >> I-125 prostate seed implant 18 months ago.  It's been 9 half life for
> >> I-125
> >> to decay since the implant.  Now he made his partner pregnant.  He
> >> asked me
> >> if it is safe to keep the baby?  The sperms stay in the semminal
> >> vessicle
> >> for a short period of time (2 weeks at most?).  I can estimate the
> >> dose to
> >> the sperm by calculating the dose to the semminal vessicle for 2
> >> weeks.  But
> >> I don't know it is safe to have the baby.  Is there anybody knowing
> >> the
> >> answer and like to share the answer with me?  Please respond in
> >> private
> >> e-mail.  Thanks
> >>
> >>
> >> Haoran Jin,  Ph.D.
> >> hjin@epix.net
> >>
> >>       ***********     ************
> >> Frequently Asked Questions (FAQ) for Medphys at:
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> >>
> >> Archives of recent Medphys Postings at:
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> >>
> >
> >===
> >Douglas Pfeiffer, MS, DABR
> >Presbyterian/St. Luke's Medical Center
> >Medical Physics
> >1719 E. 19th Ave.
> >Denver, CO  80218
> >(303)839-6548
>
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