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Re: Alternative Iodine Administration Mechanism
Gene
I don't remember the paper, I'll try to find it. And I have not followed
this thread, other than by the subject lines of the postings, so I may be
speaking to the wrong issue. But, while the ingestion/absorption of small
quantities of stable iodine can measurably reduce the avidity of the
thyroid for the element (patients who are to receive doses of radioiodine
are put on iodine-free diets, and should also be restricted from the use of
Betadine, etc.), it seems unlikely that one can completely block it that
way. I don't remember the NCRP recommendations as to dosage, but, clearly,
blocking must require scores of milligrams, with very rapid uptake. Here
please note that the ICRP half-time of residence in the stomach is 0.5 h.
Regards
cja
At 11:43 AM 11/2/99 -0600, you wrote:
>The recent thread about methods of blocking iodine brought to mind a paper by
>Moody, et al., (1988), "The Effects of Topical Povidone Iodine Solution on
Serum
>Iodide Levels and Thyroid Uptake of I-131 in Dogs," Health Physics
55:1(9-13).
>They described what sounded like very good iodine protection from painting
>2-1/2% of the skin area with Betadine. My check of ICRP23 suggested that
for an
>adult this would be about 450 square centimeters and for an infant about
75 sq
>cm. I put this in the back of my brain as an interesting alternative to oral
>administration without the potential reactions which might be associated with
>oral administration. Has anyone ever heard of any further work in this area?
>
> Gene Carbaugh, CHP
> Internal Dosimetry
> Pacific Northwest National Laboratory
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