Gordon Research Conference on Cancer Genetics & Epigenetics

["Michael P. Grissom" <mpg1@coastside.net>]

radsafe'rs,

The BEIR VII committee will have to deal with some
of the issues being raised based on genetics studies
in general (not just limited to cancer) and some of the
recent reports from the RERF.

Those of you interested on the nitty-gritty details at
the frontiers of these subjects may be interested in
the upcoming CY 2000 Gordon Research
Conference in Ventura, California, USA:

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Cancer Genetics & Epigenetics
New Insights into DNA Alterations in Neoplasia

February 20-25, 2000
Ventura Beach Hotel
Ventura, CA

Chair:	Bill Bennett, City of Hope, Los Angeles
Co-Chair:	Jill James, National Center for
		 Toxicologic Research, Jefferson,
		 Arkansas
Vice-Chair:	Ben Tycko, Columbia University, New
		 York

Session Topics & Speakers

DNA Methylation I
Discussion Leader: Art Riggs, City of Hope

   o	Peter Jones, USC, Los Angeles - Control of de
	 novo methylation in the cell cycle
   o	Gerd Pfeifer, City of Hope - Cytosine
	 methylation determines hot spots of DNA
	 damage in the human p53 gene
   o	Rudolf Jaenisch, Whitehead Institute,
	 MIT - presentation title pending
   o	Paul Goodfellow, Washington University, St.
	 Louis - hMLH1 silencing by methylation in
	 endometrial cancers

Genomic Imprinting
Discussion Leader: Peter Jones, USC

   o	Rosanna Weksberg, University of
	 Toronto - "Loss of Imprinting" of IGF2 in
	 Beckwith-Wiedeman Syndrome; Clinical
	 features & genotype/phenotype correlations
   o	Michael J. Higgins, Roswell Park Cancer
	 Institute, Buffalo - Chromosome 11p15
	 imprinting and BWS
   o	Jeff Mann, City of Hope - Non-differentially
	 methylated DNA regions in H19 and Igf2
	 imprinting
   o	An Additional Speaker will be chosen from
	 abstracts

DNA Repair & Apoptosis I
Discussion Leader: Ted Krontiris, City of Hope

   o	Frank McKeon, Harvard
	 University - Checkpoint Functions & the p53
	 Family
   o	Paul Russell, Scripps Institute, La
	 Jolla - Chk1/Cdc25 Pathway at the DNA
	 Repair "Checkpoint"
   o	John Petrini, University of Wisconsin,
	 Madison - Checkpoints, NBS and Rad52
	 epistasis group
   o	An Additional Speaker will be chosen from
	 abstracts

DNA Repair & Apoptosis II
Discussion Leader: To Be Announced

   o	Ralph Scully, Harvard University - BRCA1,
	 BRCA2 and Rad51 operate in a common DNA
	 Damage Response Pathway
   o	Richard Baer, Columbia University - Novel
	 BRCA1 and BRCA2 Interacting Proteins
   o	Tom Ludwig, Columbia University - Analysis of
	 BRCA1 & BRCA2 in a Murine Knockout Model
   o	An Additional Speaker will be chosen from
	 abstracts

Cancer Susceptibility Genes
Discussion Leader: Bill Bennett, City of Hope

   o	Alice S. Whittemore, Stanford
	 University - Genetically Tailored Preventive
	 Strategies: A Plan for the 21st Century?
   o	Edward Giovannucci, Harvard
	 University - Folate, methylene tatrahydrofolate
	 reductase and colorectal cancer
   o	William G. Kaelin, Dana-Farber Cancer
	 Institute, Boston - The Von-Hippel Lindau
	 Tumor Suppressor Gene Paradigm
   o	An Additional Speaker will be chosen from
	 abstracts

Chemoprevention
Discussion Leader: Bruce Ames, UC Berkeley

   o	Bruce Ames, UC Berkeley - Prevention of
	 cancer and delay of aging with micronutrients
   o	Frank L. Meyskens, UC Irvine - Regulation of
	 polyamine metabolism as an approach to
	 chemoprevention of human cancer
   o	Ernie Hawk, NCI, NIH, Bethesda - COX-2
	 inhibition as a chemopreventive strategy - from
	 premise to promise
   o	Stephen D. Hursting, NCI, NIH,
	 Bethesda - Mechanism-based cancer
	 prevention approaches: targets, examples and
	 use of transgenic mice

Molecular Epidemiology: Gene-Environment
  Interactions
Discussion Leader: Robert W. Haile, USC

   o	Margaret R. Spitz, UT M.D. Anderson Cancer
	 Center - Molecular epidemiology of lung
	 cancer
   o	Christine Ambrosone, National Center for
	 Toxicologic Research - Use of molecular
	 epidemiology to explore paradigms of
	 carcinogenesis in hormonally-responsive tissue
   o	John Potter, University of Washington,
	 Seattle - Colorectal neoplasia: at the interface
	 of population and molecular biology
   o	Laverne Mooney, Columbia
	 University - Antioxidant vitamin interventions in
	 high-risk populations

DNA Methylation II
Discussion Leader: Ben Tycko, Columbia University

   o	Steve Baylin, Johns Hopkins University - The
	 role of promoter regions in gene silencing in
	 cancer
   o	Sandy Markowitz, Case Western Reserve
	 University - DNA repair genes and TGF-ß
	 receptors, coupled targets in colon
	 carcinogenesis
   o	Tim Bestor, Columbia University - DNA
	 methylation and hypomethylating genetic
	 syndromes
   o	Melanie Ehrlich, Tulane University - The ICF
	 syndrome & cancer: DNA hypomethylation &
	 chromosomal rearrangements

Chromosomes & Chromatin
Discussion Leader: Alan Wolffe, NICHHD, NIH,
  Bethesda

   o	Alan Wolffe, NICHHD, NIH, Bethesda - Cancer
	 epigenetics: biochemical mechanisms that
	 connect DNA methylation, chromatin
	 remodeling, histone deacerylation and
	 transcription
   o	Martin Smith, Indiana Univ. Cancer Ctr.,
	 Indianapolis - Chromatin changes with mutant
	 p53 and loss of cell cycle control
   o	Mat Thayer, Oregon Health Sciences
	 University, Portland - ATR, DNA Damage
	 Sensing & Chromosome
	 Structure/Rhabdomyosarcoma
   o	An Additional Speaker will be chosen from
	 abstracts


----------
The above may be viewed on the Web at:

	http://www.grc.uri.edu/programs/2000/cangen.htm




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