Re: DSBs

[Bernard L Cohen <blc+@pitt.edu>]

	I am not at all an expert on this subject but it is my
understanding that the double strand breaks due to radiation are
indistinguishable from the double strand breaks due to chemical and
thermal effects. For more details on this, you might contact Myron
Pollycove at mxp@nrc.gov.

Bernard L. Cohen
Physics Dept.
University of Pittsburgh
Pittsburgh, PA 15260
Tel: (412)624-9245
Fax: (412)624-9163
e-mail: blc+@pitt.edu


On Wed, 22 Dec 1999, Karam, Andrew wrote:

> From: Bjorn Cedervall [mailto:bcradsafers@hotmail.com]
> 
> I think that it may be important to consider the types of DSBs and also how 
> they are detected (a DSB detected by some assays may biologically be 
> recognized and repaired as 2 SSBs). A DSB handled by the topoisomerase II 
> system is well defined whereas DSBs caused by ionizations probably & usually
> 
> are not "clean" and more of ruptures that differ from DSB to DSB (abasic 
> sites, at least two SSBs, base damages in different combinations and with 
> different spacial relationships).
> =======================
> 
> This is interesting, Bjorn.  Does this mean that there is a qualitative
> difference between DSB's caused by high-LET, low-LET radiations and
> non-radiation events?  If so, would each of these types of DSBs have a
> different probability of repair?  Or would some be more likely lethal than
> others?  I just assumed that all DSBs were pretty much the same. 
> 
> Andy
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