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Re: Enhanced immune response??
- To: radsafe@romulus.ehs.uiuc.edu, ans-pie@nuke-ans.org, rad-sci-l@ans.ep.wisc.edu
- Subject: Re: Enhanced immune response??
- From: Muckerheide <muckerheide@mediaone.net>
- Date: Mon, 31 Jan 2000 14:41:29 +0000
- CC: "Tschaeche, Al" <antatnsu@pacbell.net>, "Lilley, Floy" <lilypad@mail.utexas.edu>, "Muckerheide, Jim" <jmuckerheide@delphi.com>, "Fumento, Michael" <mfumento@compuserve.com>, "Pollycove, Dr. Myron" <mxp@nrc.gov>, "Cameron, John" <jrcamero@facstaff.wisc.edu>, "Maxey, Dr. Margaret" <dr.maxey@mail.utexas.edu>, "Paperiello, Dr. Carl" <cjp1@nrc.gov>, "dePlanque, Dr. Gail" <gdeplanque@aol.com>, "Muntzing, L. 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- References: <c0.ef5c56.25c65d12@aol.com>
- Reply-To: muckerheide@mediaone.net
Bill,
Disingenuous. The issue was whether homeo's use hormesis research to
support homeopathy, not the reverse. They do. Hormesis is real.
(Hormesis is a biological function, not limited to radiation.)
Why do you not consider that the immune response indicates reduction
of cancer? Almost weekly there are medical research reports of using
immune system stimulation to treat cancer. (LDR is not the only
stimulator of immune response - see the chemical hormesis and
pharmocology literature.)
How many times do you have to get refs on LDR/cancer?
>>>>>
Getting more specific to just a couple of examples, see, from Dr. Pollycove:
"Low-dose stimulation of the immune system may not only prevent cancer
by increasing removal of pre-malignant or malignant cells with
persistent DNA damage, but may also destroy gross cancer growths with
metastases (Figure 17) [ref] 35.
http://cnts.wpi.edu/rsh/Figures/Docs/MP98_fig17.gif
Recently Sakamoto, et al at Tohoku University, Sendai, Japan have
reported successfully treatment of non-Hodgkins lymphoma with total or
half body low-dose radiation35. Half body irradiation (HBI) of the rib
cage area (thorax from xyphoid process to suprasternal notch) was as
effective as whole body irradiation (TBI). Fractionated doses of 10
cGy 3x/week or 15 cGy 2x/week were given for 5 weeks for a cumulative
dose of 150 cGy (Figure 18).
http://cnts.wpi.edu/rsh/Figures/Docs/MP98_fig18.gif
In some patients tumors completely outside the HBI field disappeared
after HBI alone (Figure 19) 36.
http://cnts.wpi.edu/rsh/Figures/Docs/MP98_fig19.gif
Analysis of peripheral lymphocytes demonstrated immune system
stimulation. The 10 year survival of patients receiving only local
high-dose radiotherapy and chemotherapy is 50% compared to 84% 9 year
survival of patients (no deaths after 3.7 years) receiving additional
low dose TBI or HBI. (P<0.05, Figure 20)."
http://cnts.wpi.edu/rsh/Figures/Docs/MP98_Fig20.gif
Refs:
35. Sakamoto K, Myogin M. Hosoi Y, Ogawa Y, Nemoto K, Takai Y, Kakuto
Y, Yamada S, Watabe M. Fundamental and clinical studies on cancer
control with total or upper half body irradiation. J. Jpn. Soc. Ther.
Radiol. Oncol. 9:161-175 (1997).
36. Takai Y, Yamada S., Nemoto K, Ogawa Y, Kakutou Y, Hosi A, Sakamoto
K. Anti-tumor effect of low dose total (or half) body irradiation and
changes in the functional subset of peripheral blood lymphocytes in
non-Hodgkins lymphoma patients after TBI (HBI). In: Low Dose
Irradiation and Biological Defense Mechanisms (Sugahara T, Sagan LA,
Aoyama T, eds). Amsterdam, the Netherlands: Elsevier Science
Publishers, 1992: 113-116.
>>>>>
See also:
http://cnts.wpi.edu/rsh/Data_Docs/1-2/3/3/12334ta91.html
Takai, Y., Ogawa, Y. Nemoto, K., Yamada, S. and Sakamoto, K. (1991)
Direct anti-tumor effect of low dose total (or half) body irradiation
and changes of the functional subset of peripheral blood lymphocytes
in non-Hodgkinís lymphoma patients after TBI (HBI), J. Jpn. Soc. Ther.
Radiol. Oncol. 3: pp9-18.