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Radon and never-smokers in Sweden
Dear Jim,
I'm not saying the subjects lied. The recall bias I mentioned is an attempt to
explain the discrepancies in Table 6 of the Swedish study between subjects
exposed to ETS and not exposed. The authors gave no explanation for this
important result.
My atttempt is based on results from the Schneeberg Study when the smoking habit
was validated and results from an ongoing uranium miners study. When comparing
the self-reported smoking status of lung cancer cases prior to diagnosis (data
from medical records when x-rayed for lung diseases and tuberculosis) and at
time of diagnosis (interviewed in the lung cancer registry) resulted in an
obvious tendency by lung cancer cases to minimise and even deny their smoking
behaviour. This could apply to never-smokers from the Swedish study too. It is
humane. When being certain to include never-smokers in your study you cannot
rely on the self-reported smoking history at time of diagnosis for lung cancer.
People with lifestyle related diseases tend to minimise their own contribution
or try to put the blame on other reasons. You can find extensive literatur about
this, try AJE or ask your physician.
As BEIR VI stated, the lung cancer risk from smoking amounts to 10-20 and that
from indoor radon to 0,2-0,3 only. Risk estimations for lung cancer due to
indoor radon react therefore very sensitive to misspecifications of cigarettes
smoked. Even with a misspecification of one cigarette per day only over about 30
years the relative error comprises 13%.
Karl
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PreCura Institute for Preventive Medicine
Dr. Karl Martin
Auguststraße 2
D-16321 Schönow
FON/FAX 0049 3338 3221
e-mail: precura.martin@t-online.de
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