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Re: I-131 dose to pregnant woman





I've basically no experience in this matter but I was rather struck by some of

the numbers in this table.  The 2.4 rem (24 mSv, ca. 24 mGy) to the uterus (and

therefore foetus?) seems to agree with what others have suggested.  I note

however that the thyroid dose is "only" (quotes indicating my uneducated

reaction) 2.6 rem, most other organs considered in the program seem to get

greater doses.  Now my limited education includes the thought that iodine is

supposed to concentrate in the thyroid and that the purpose of giving I-131 to

such a patient is to deliver a dose to the thyroid.  The numbers produced below

would seem to suggest that in fact it is not very efficient.  Why is this so?

Anyone care to educate me? (in brief I hope :-) )



Peter Thomas

ARPANSA







I took this question to a very knowledgeable colleague who ran the numbers

through an internal dosimetry program called RSAC using ICRP 39 model of

the human body this is the info he came up with.



Assuming the dose is in milli curies and NOT micro curies (If micro that of

course would reduce the dose by a factor of 1000)



Another caveat is that these doses are to the mother and the fetal tissue

has not yet differentiated into organ at 1 - 2 weeks of gestation.



I don't think a dose to the mother's uterus warrants a therapeutic abortion

|--------------------+--------------------|

|Organ receiving dose|Dose to organ in REM|

|--------------------+--------------------|

|      Adrenals      |         3          |

|--------------------+--------------------|

|    Bladder Wall    |        2.3         |

|--------------------+--------------------|

|    Bone surface    |        4.8         |

|--------------------+--------------------|

|       Breast       |        6.7         |

|--------------------+--------------------|

|     Esophagus      |        17.1        |

|--------------------+--------------------|

|      Stomach       |         17         |

|--------------------+--------------------|

|Small Intestine Wall|        2.5         |

|--------------------+--------------------|

|    Upper Large     |        2.5         |

|   Intestine Wall   |                    |

|--------------------+--------------------|

|    Lower Large     |        2.4         |

|   Intestine Wall   |                    |

|--------------------+--------------------|

|      Kidneys       |        2.5         |

|--------------------+--------------------|

|       Liver        |        2.7         |

|--------------------+--------------------|

|       Lungs        |        5.7         |

|--------------------+--------------------|

|       Muscle       |        6.7         |

|--------------------+--------------------|

|      Ovaries       |        2.3         |

|--------------------+--------------------|

|      Pancreas      |        3.3         |

|--------------------+--------------------|

|  Red Bone Marrow   |        5.2         |

|--------------------+--------------------|

|        Skin        |        4.6         |

|--------------------+--------------------|

|       Spleen       |        3.1         |

|--------------------+--------------------|

|       Thymus       |        17.1        |

|--------------------+--------------------|

|      Thyroid       |        2.6         |

|--------------------+--------------------|

|       Uterus       |        2.4         |

|--------------------+--------------------|





Dear Colleagues;



A 23 year old woman received 14.6 mc I-131 for hyperthyroidism.

A few days later it became apparent that she had conceived one week before

receiving the I-131.



In other words the 14.6 mc were given in her 1-2 first weeks of pregnancy.

She is now 5-6 weeks pregnant.



Should abortion be considered in view of possible damage to the fetus ?



Your fast opinion is very important.





Thanks,



Moshe Levita

Ministry of Health, Israel



mlevita@netvision.net.il









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