Re: Animal radon studies

[epirad@mchsi.com]

A good starting point would be the summary in BEIR IV. 

http://books.nap.edu/books/0309037972/html/430.html#paget

op





Radiat Environ Biophys 2001 Dec;40(4):269-77	

[]

A consistent two-mutation model of lung cancer for 

different data sets of radon-exposed rats.



Bijwaard H, Brugmans MJ, Leenhouts HP.



National Institute for Public Health and the Environment 

(RIVM), Bilthoven, The Netherlands. 

Harmen.Bijwaard@RIVM.nl



A two-mutation carcinogenesis model, formulated in terms 

of biologically motivated equations for mutation and 

expansion steps, has been applied in a mechanistic 

modelling of the lung cancer incidence in two large data 

sets of rats exposed to radon, both separately and 

jointly. Results indicate that (1) the equations 

employed are able to provide an accurate description of 

the separate data sets, (2) the parameters in the 

equations take on similar values for both data sets, and 

(3) it is possible to construct a consistent and well-

fitting solution for the joint data set. It proved not 

to be necessary to take into account the effect of 

uranium ore dust, administered to part of the data or 

the different rat strains of the data sets. The joint 

solution provides a firm basis to investigate the 

effects of exposure, exposure rate and age at exposure 

on cumulative incidence, excess relative risk and excess 

absolute risk. For the same total exposure, cumulative 

incidence reaches a maximum for exposure rates between 1 

and 10 WLM per day. The so-called inverse-exposure-rate 

effect acts for higher exposure rates. The influence of 

age at exposure, however, seems to be even more 

pronounced. Exposure at a young age leads to 

considerably higher incidences than exposure at a later 

age. Parameters derived in this study compare fairly 

well with those derived for uranium miners, suggesting 

that a consistent model description for the induction of 

lung cancer by radon in rats and humans may be possible.



----------------------------

> 

> Does anyone know if there have been any animal studies of radon vs lung

> cancer?  I am hoping for a reference that I can look up.

> 

> Thanks,

> 

>     _______________________________________________

> 

> 	Gary Isenhower

> 	713-798-8353

> 	garyi@bcm.tmc.edu

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