Calabrese and Baldwin again

[Muckerheide <muckerheide@attbi.com>]

Friends,



A further treatment of the subject by Calabrese and Baldwin.



It is a review that even explicitly addresses the self-serving resistance to

well-established science results by political and government agencies, and

their industries that profit from the policies.





Calabrese EJ, Baldwin LA.

Hormesis: The Dose-Response Revolution.

Annu Rev Pharmacol Toxicol 2002 Aug 19

Department of Environmental Health Sciences, University of Massachusetts,

Amherst, MA 01003-5712.



Hormesis, a dose-response relationship phenomenon characterized by a

low-dose stimulation, high-dose inhibition, has been shown to be frequently

observed in properly designed studies as well as broadly generalizable being

independent of chemical/physical agent, biological model and endpoint

measured. This under-recognized and -appreciated concept has the potential

to profoundly change toxicology and its related disciplines with respect to

study design, animal model selection, endpoint selection, risk assessment

methods, and numerous other aspects, including chemotherapeutics among

others. This article indicates that as a result of hormesis fundamental

changes in the concept and conduct of toxicology and risk assessment should

be made including: (a) the definition of toxicology; (b) the process of

hazard (e.g., including study design, selection of biological model, dose

number and distribution, endpoint measured, and temporal sequence) and risk

assessment (e.g., concept of NOAEL, low dose modeling, recognition of

beneficial as well as harmful responses) for all agents; and (c) the

harmonization of cancer and non-cancer risk assessment.



http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list

_uids=12195028&dopt=Abstract



Let me know if you will review either of these papers.



Regards, Jim



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