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Jim,
Why don't you read the article, and not just the abstract. A review of what is known about the nature of genetic damage and repair mechanisms might also be helpful. (I would avoid high school text books, as they are usually dated.) If you have not read the article, how do you know what the authors are saying? If you have not read the article, how can you say others are wrong? In the abstract they say:
the irradiation creates the conditions for their liquidation. Based on the analysis and correlation of these phenomena the time-dependent theory for DNA degradation was created, including hormesis phenomenon, radiation antagonism, the validity of anomaly influence of low and large doses at sharp and chronic irradiation and other effects. A qualitative and quantitative agreement of the theory and experimental results was obtained. I bet radiation antagonism is not a good thing. Also, I do not see "enhanced repair" in the material you set. You are not making that up, are you? -- John John P. Jacobus, MS, CHP 3050 Traymore Lane Bowie, MD 20715 jenday@msn.com (H) ------------------------ On Mon, 11 Nov 2002 06:47:30 -0500 Jim Muckerheide wrote: > Subject: Re: Hormesis in DSB formation and repair > > on 11/11/02 1:06 AM, Bjorn Cedervall at bcradsafers@HOTMAIL.COM wrote: > > >> Even if this were true, what's the point? > > > > That with each DSB the cell statistically moves one step further into either > > towards genomic chaos or cell death. > > You're not saying that the authors of this paper are considering misrepair > in their measure of "enhanced repair"? > > > > Bjorn Cedervall > > ---------------------- > >>> Further indication of hormetic effects in the dynamics of DSB formation > > and repair by irradiation. > >> > >> Much of mammalian repair of DSBs is actually misrepair (misrejoining) and > > information is lost in the cell. > > > And how much do you mean by "much?" > > (And rad-induced DSBs are trivial in endogenous DSBs?) > > Thanks, > Regards, Jim . . . |