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RE: Emergency Preparedness
Today Brazil is one of the countries with large experience gained in the
use of Prussian Blue Therapy in the treatment of contaminated persons due
Cs-137.
To those interested it is possible download the IAEA doc. describing the
Brazilian experience on Dosimetric and Medical Aspects in Goiania,
especially:In Vitro and In Vivo Bioassay, Cesium Biokinetic Model Efficacy
of Prussian Blue Therapy for decorporation of Cesium, Cesium Metabolism in
Pregnant Women Internal Dose Assessment, Dose Assessment and Cytogenetic
Follow-Up Clinical Aspects and Treatment of Localized Radiation-Induced
Lesions, The infectious complications and Hematological Disorders in the
Goiania Radiation Accident Victims, The Medical Follow-Up to the present.
Please GO TO http://www-pub.iaea.org/MTCD/publications/PDF/te_1009_prn.pdf
to download the Dosimetric and Medical Aspects of the Radiological Accident
in Goiânia in 1997 Details IAEA TECDOC Series No. 1009 1998
If colleagues wish to discuss technically materials, please select the
subject, send me e-mail and I’ll provide the e-mail to communicate with the
Brazilian group on the topic.
Jose Julio Rozental
joseroze@netvision.net.il
Brazil until January 28
Original Message:
-----------------
From: Engelbretson, David A. DEngelbret@TMH.TMC.EDU
Date: Mon, 06 Jan 2003 13:43:40 -0600
To: radsafe@list.vanderbilt.edu
Subject: Emergency Preparedness
Dear Colleagues,
In regard to chemical agents used for treating certain types of RAM
exposures, are there any substitutes available for the following two
chemicals ?
Ferric ferrocyanide (Prussian Blue), a blocking agent for Cs-137, is not
recognized by the U.S. Pharmacopeia and is not approved by the FDA.
DTPA, a chelating agent, is not commercially available either. I believe it
is only available under Investigational New Drug (IND) permits for treatment
of persons contaminated internally with plutonium. However, calcium EDTA is
available and has effectiveness for the transuranium metals, but DTPA is
generally more effective.
Any assistance or direction would be appreciated. Thank you.
David Engelbretson
Radiation Safety Dept.
Methodist Hospital, Houston, Texas
dengelbret@tmh.tmc.edu <mailto:dengelbret@tmh.tmc.edu>
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