FW: Epidemiological musings of a non-biologist

["Bradt, Clayton" <Clayton.Bradt@Labor.State.Ny.Us>]

-----Original Message-----

From: Bradt, Clayton 

Sent: Tuesday, June 10, 2003 9:23 AM

To: 'epirad@mchsi.com'

Subject: RE: Epidemiological musings of a non-biologist





Actually, I think all you have is an estimate of the time-average airborne

concentration of radon in each home, combined with an estimate of how much

time each individual spent in the home, right?  That information is assumed

to be linearly related to lung dose.  But the lung consists of many

populations of cells of various cell types. The lung dose is an average

representing the dose to every cell in the lung. 



-----Original Message-----

From: epirad@mchsi.com [mailto:epirad@mchsi.com]

Sent: Monday, June 09, 2003 6:14 PM

To: Bradt, Clayton

Subject: RE: Epidemiological musings of a non-biologist





No, with case-control radon studies you know the exposure to the lungs for 

each individual.  In an ecologic study, you have a few short term screening 

measurements per county representing the radon dose to everyone in the 

county.  



  

> Bill,

> 

> Thanks for the references.  My issue, though, is not so much the problems

> with ecologic studies, but rather whether all studies relating dose

> (inherently an average quantity either over a group of individuals, or

> organs, tissue types, cells or molecules) to cancer, are not in fact

> ecologic studies?

> 

> Clayton

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