Re: Monoclonal Antibody Therapy

[Chris Alston <alstonc@odrge.odr.georgetown.edu>]

Scott

The problem would be in meeting the 500 mrem limit for the general public
(questions of contamination aside). It's my recollection that it typically
takes 5 - 11 days to clear the body burden to fulfill the "30-millicurie
rule", in I-131 RIT. However, it's been several years since I had anything
to do with it. I'm forwarding your question to the Radsafe list; maybe
someone there has more definitive info.

chris alston
alstonc@odrge.odr.georgetown.edu
I speak not here for my employer.

At 01:23  03/05/98 -1000, you wrote:
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>Our Nuclear Medicine physician would like to enroll patients on a protocol
>which uses I-131 labeld monoclonal antibodies to treat Non-Hodgkin's
>Lymphoma.  The patient will be injected with up to 200 mCi of I-131.
>
>The protocol document states the biological half life for the blood is
>approximately 3 hours for the "fast phase" and 31 hours for the "slow
>phase".  But it doesn't describe the typical body clearance time.
>
>Our physician would like to do these patients on an out-patient basis, just
>like our NaI-131 thyroid ablation patients.  So here are my questions:
>
>Does NUREG-1492 apply to monoclonal antibody therapy?  Does anyone
>have any experience with this protocol?  How would you proceed?
>
>Thanks for whatever you can offer.
>