[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]
Re: 1994 Estonia Incident
Picked up the text below from Medline. I would suggest a contact with
Dr. Carita Lindolm at STUK (the Finnish Radiation Protection
Institute)./Bjorn
Biodosimetry after accidental radiation exposure by conventional
chromosome analysis and FISH.
Lindholm C, Salomaa S, Tekkel M, Paile W, Koivistoinen A, Ilus T,
Veidebaum T
Finnish Centre for Radiation and Nuclear Safety, Department of Research,
Helsinki, Finland.
A 137Cs source was stolen from a radioactive waste depository in Estonia
on 21 October 1994 and kept in a private house for 4 weeks. This
resulted in the death of one person, acute radiation injuries to four
people and exposure of several other people to lower doses of radiation.
Analysis of chromosomal aberrations in peripheral blood lymphocytes was
used in the assessment of radiation exposure of 18 people involved in
the accident. Dose estimation assessment based on the frequencies of
dicentric chromosomes was performed both by the standard method and by
considering possible dose protraction and non-uniform exposure.
Considerable differences in dose estimates were obtained depending on
the approach used, ranging from about 1 Gy to almost 3 Gy in the
patients most heavily exposed. In view of the deterministic health
effects observed in some of the subjects, it was concluded that the dose
estimates involving information on dose protraction were more realistic
than those obtained by comparison with the standard high dose-rate
calibration curve. Chromosome painting analyses using fluorescence in
situ hybridization, with a probe cocktail for chromosomes 1, 2 and 4 and
centromere detection, were performed in parallel. Good agreement on
dicentric chromosome frequencies was observed between the conventional
and painting analyses. The frequencies of complete translocations were
comparable with the frequencies of dicentric chromosomes. In addition to
the complete translocations, a pronounced increase in the frequency of
incomplete translocations was observed. Dose estimates performed on the
basis of FISH translocation frequencies were consistent with the
dicentric analysis.
---------------------------------------------------------------
bjorn_cedervall@hotmail.com
Depts. Medical Radiation Biology and Medical Radiation Physics,
Karolinska Institutet, Box 260,
S-171 76 Stockholm, Sweden
Ph/fax: Int + 468 343525 (Med. Radiation Physics)
Website: http://www.geocities.com/WallStreet/Exchange/8256/
______________________________________________________
Get Your Private, Free Email at http://www.hotmail.com
************************************************************************
The RADSAFE Frequently Asked Questions list, archives and subscription
information can be accessed at http://www.ehs.uiuc.edu/~rad/radsafe.html